Most of the patients suffering from cystic fibrosis present an exocrine insufficiency of the pancreatic function leading to complex digestive disorders. 8 patients between 1 and 12 years old with the diagnosis of cystic fibrosis are studied. Pancreatic enzymes in serum, protein electrophoresis, and viral markers of hepatitis B and C were carried out. Abdominal ultrasound, esophageal, hepatic and biliary gammagraphy were also performed. The most frequent clinical manifestations were steatorrhea, abdominal colics and hepatomegalia. Augmented lipase in serum was found in two patients with pancreatic sufficiency, whereas transaminases were normal in all of them. 3 patients showed clinical manifestations and 2 had gastroesophageal reflux and rectal prolapse, respectively. It was observed that with the therapeutic control of these manifestations a good nutrional status and a better quality of life are reported.

La mayoría de los pacientes con fibrosis quística presentan una insuficiencia exocrina de la función pancreática que entraña trastornos digestivos complejos. Se estudian 8 pacientes entre 1 y 12 años con el diagnóstico de fibrosis quística. Se les realizó enzimas pancreáticas en suero, electroforesis de proteínas y marcadores virales de la hepatitis B y C. También se les efectuó ultrasonido abdominal, gammagrafía esofágica, hepática y biliar. Las manifestaciones clínicas más frecuentes fueron la esteatorrea, cólicos abdominales y hepatomegalia. Se encontró la lipasa aumentada en suero en 2 pacientes con suficiencia pancreática y las transaminasas normales en todos ellos. Las manifestaciones hepáticas estuvieron presentes en 3 pacientes y el reflujo gastroesofágico y el prolapso rectal en 2, respectivamente. Se observó que el control terapéutico de estas manifestaciones reportan un buen estado nutricional y mejor calidad de vida.

Among patients suffering from cystic fibrosis the Pseudomonas aeruginosa is the most important pathogen as a cause of chronic pulmonary infection and it has been proved that lung inflammatory response may contribute to the pathogenesis of this infection, with the participation of specific and unspecific defence mechanisms. Therefore, clinical and microbiological manifestations are correlated in 9 patients with cystic fibrosis. Patients were diagnosed by the clinic and electrolites in sweat and it was carried out a microbiological study of sputum or deep swab, where the Pseudomona aeruginosa was isolated in all cases. Antipseudomona aeruginosa antibodies in serum were determined and the results were connected with the clinic. Elevated titres were obtained in all patients in different determined serotypes and there was a relationship between antibody titres and clinical manifestations. A decrease of titres in patients treated with steroids or under antipseudomona treatment was also observed.

En pacientes con fibrosis quística la Pseudomonas aeruginosa es el patógeno más importante como causa de infección pulmonar crónica y se ha demostrado que la respuesta inflamatoria del pulmón puede contribuir a la patogénesis de esta infección, con la participación de los mecanismos de defensa específicos e inespecíficos; por lo que se correlacionan las manifestaciones clínicas y microbiológicas en 9 pacientes con fibrosis quística. Los pacientes se diagnosticaron por la clínica y electrólitos en sudor y se les realizó estudio microbiológico de esputo o hisopado profundo, donde se aisló en todos los casos la Pseudomona aeruginosa. También se determinaron en suero los anticuerpos antiPseudomona aeruginosa y se relacionaron los resultados con la clínica. En todos los pacientes se obtuvieron títulos elevados en distintos serotipos determinados y existió relación entre los títulos de anticuerpos y las manifestaciones clínicas. Igualmente se observó disminución de los títulos en los pacientes tratados con esteroides o con tratamiento antiPseudomona.

Foi realizada uma revisão completa da Dengue Hemorrágica, doença infecciosa viral aguda e potencialmente, grave, transmitida por mosquito, que, em 1981, causou a morte de 158 pessoas durante uma epidemia em Cuba, sendo 101 menores de 15 anos. A Dengue, em sua forma clássica (benigna), foi primeiramente referida em 1823, porém,no ano de 1953, em Manila, Filipinas, se registrou uma nova apresentação da doença, caracterizada por manifestações hemorrágicas, choque e alta mortalidade que se denominou Febre Hemorrágica Dengue e Síndrome de Choque por Dengue (FHD/SSD). Sua patogenia é apresentada, discutindo-se também a possibilidade de repetição do fenômeno nas Américas.

A thorough revision on hemorragic dengue fever is presented. Dengue, an acute mosquito-borne infectious disease has occurred in epidemic form in Cuba 1981, causing death of 158 persons. The disease in its classical form was first reported in 1823 but in 1953 a new presentation characterized by hemorrhagic manifestations, shock and a high mortality was observed in Manila, Phillipines. This form was called Hemorrhagic Dengue Fever and Dengue Shock Syndrome (HDF/DSS). Its pathogenesis can be explained by two different theories: it could be a primary infection or a hipersensibility reaction depending on a previous infection.

Foi realizada uma revisão completa da Dengue Hemorrágica, doença infecciosa viral aguda e potencialmente, grave, transmitida por mosquito, que, em 1981, causou a morte de 158 pessoas durante uma epidemia em Cuba, sendo 101 menores de 15 anos. A Dengue, em sua forma clássica (benigna), foi primeiramente referida em 1823, porém,no ano de 1953, em Manila, Filipinas, se registrou uma nova apresentação da doença, caracterizada por manifestações hemorrágicas, choque e alta mortalidade que se denominou Febre Hemorrágica Dengue e Síndrome de Choque por Dengue (FHD/SSD). Sua patogenia é apresentada, discutindo-se também a possibilidade de repetição do fenômeno nas Américas.

A thorough revision on hemorragic dengue fever is presented. Dengue, an acute mosquito-borne infectious disease has occurred in epidemic form in Cuba 1981, causing death of 158 persons. The disease in its classical form was first reported in 1823 but in 1953 a new presentation characterized by hemorrhagic manifestations, shock and a high mortality was observed in Manila, Phillipines. This form was called Hemorrhagic Dengue Fever and Dengue Shock Syndrome (HDF/DSS). Its pathogenesis can be explained by two different theories: it could be a primary infection or a hipersensibility reaction depending on a previous infection.

Uma epidemia de Dengue hemorrágica ocorreu em Cuba no ano de 1981. Entre a população de cerca de 10 milhões de habitantes, registraram-se 344.203 casos, sendo 71,3% em adultos e o restante crianças, entre as quais a doença se apresentou com maior gravidade. Durante o pico da epidemia, foram notificados 11.271 casos em um único dia. Neste trabalho se expõem os aspectos organizativos do atendimento médico durante a epidemia e o estudo realizado em 2239 pacientes hospitalizados com diagnóstico confirmado de Dengue hemorrágica, em três hospitais da Cidade de Havana, no período junho - agosto de 1981. Apresentam-se as principais manifestações clínicas e humorais de uma amostra de 2239 pacientes menores de 15 anos de idade. Discute-se ainda alguns aspectos terapêuticos, inclusive a experiência do autor com o uso de interferon em 166 pacientes.

An outbreak of hemorrhagic dengue fever occurred in Cuba in 1981. Among a population of about 10 million people, 344.203 persons were affected; 71,3% of these were adults and the remaining were children. Among the latter the disease was more severe. During the peak of the epidemic up to 11. 701 cases were reported in one single day. In this article the organizational aspects of health care delivery durint the epidemics as well as the studies performed in the 2239 patients admited to 3 hospitals of the city of La Habana from June to August 1981 are reported. The most important clinical and laboratory data from sample of 2239 patients under 15 years of age are presented. Some therapeutic aspects, including the experience of the author with the use of in tereferon in 166 patients, are also discussed.

Uma epidemia de Dengue hemorrágica ocorreu em Cuba no ano de 1981. Entre a população de cerca de 10 milhões de habitantes, registraram-se 344.203 casos, sendo 71,3% em adultos e o restante crianças, entre as quais a doença se apresentou com maior gravidade. Durante o pico da epidemia, foram notificados 11.271 casos em um único dia. Neste trabalho se expõem os aspectos organizativos do atendimento médico durante a epidemia e o estudo realizado em 2239 pacientes hospitalizados com diagnóstico confirmado de Dengue hemorrágica, em três hospitais da Cidade de Havana, no período junho - agosto de 1981. Apresentam-se as principais manifestações clínicas e humorais de uma amostra de 2239 pacientes menores de 15 anos de idade. Discute-se ainda alguns aspectos terapêuticos, inclusive a experiência do autor com o uso de interferon em 166 pacientes.

An outbreak of hemorrhagic dengue fever occurred in Cuba in 1981. Among a population of about 10 million people, 344.203 persons were affected; 71,3% of these were adults and the remaining were children. Among the latter the disease was more severe. During the peak of the epidemic up to 11. 701 cases were reported in one single day. In this article the organizational aspects of health care delivery durint the epidemics as well as the studies performed in the 2239 patients admited to 3 hospitals of the city of La Habana from June to August 1981 are reported. The most important clinical and laboratory data from sample of 2239 patients under 15 years of age are presented. Some therapeutic aspects, including the experience of the author with the use of in tereferon in 166 patients, are also discussed.